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These findings suggest that excess hemin exposure impairs SCD erythroblasts GSH synthesis through downregulation of the TSS pathway CBS and methionine cycle AHCY
Vitamin B12, on the other hand, plays a crucial role in the synthesis of DNA, red blood cells, and the maintenance of the nervous system
Baseline vitamin B12 levels before starting metformin Annual monitoring for patients on long-term metformin therapy Consideration of vitamin B12 supplementation if deficiency is detected Antibiotics and Chemotherapy Agents That Affect B12 Metabolism Certain antibiotics and chemotherapy agents can harm vitamin B12 metabolism
When to pause or stop Most side effects resolve with time and do not require protocol changes
Sahin E, Deshmukh S
