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Dopamine signaling pathways and LRRK2 gene mutations can exacerbate mitochondrial dysfunction by interfering with H 2 O 2 /O regulatory mechanisms, further impairing the plasticity and survival of NSCs [289, 290]

Instead, there should be a growing focus on the nutrient density of the food to ensure these patients get adequate nutrition from the foods they choose to eat

"The rodent data is compelling but cannot substitute for proper clinical development" 14

Jul 2023;14(4):629-636

This typically includes measurement of IGF-1 and, where indicated, dynamic GH stimulation testing (such as an insulin tolerance test or glucagon stimulation test) and pituitary imaging