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Because the preclinical literature on each individually points at overlapping wound-repair pathways, and a single vial is operationally simpler for research that wants to compare a co-administered condition to a single-peptide condition

Many inflammatory chemokines are mainly produced by synovial macrophages and FLS in the joints of RA patients, whereas CX3CL1 is produced by synovial endothelial cells

fresh tissue replaces it

There are a few ways

The investigators proposed pairing bvPLA2 therapy with A vaccine therapy to slow the onset of Alzheimers disease while preventing harmful inflammatory responses (Baek et al., 2018)