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About this article Cite this article Krajnc, N., Itariu, B., Macher, S

This may explain the comparatively high discontinuation rate of 10.6% for those on the highest dose of orforglipron, a higher figure than the 7% observed for the investigational oral semaglutide

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Based on this neuronal projection distribution, downstream brainstem nuclei appear to regulate portion size, given their reception of vagal and circulating hormonal afferents, and can modulate food intake, digestion, and absorption (117)

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