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Both groups did not differ significantly in terms of gender

The mechanisms that link carnitine intake, S-5-HT, and fatigue, in both CFS and hypothyroidism, are yet unknown

In this combined analysis, we observe that the degree of BMI loss depends strongly on sex, drug type, time on treatment and drug dosage, consistent with previous reports 11 , and has a relatively weak dependence on pre-treatment BMI (with higher starting BMI associated with greater BMI loss)

These results represent a significant advancement over earlier GLP-1 receptor agonists and positioned tirzepatide as the clinical gold standard for pharmacological weight management heading into the mid-2020s