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Although rare, patients with a history of skin sensitivity or allergies should be monitored closely for any adverse reactions
Furthermore, Apigenin attenuates DR by elevating miR-140-5p expression to inhibit the HDAC3/PTEN/PI3K/AKT pathway, as demonstrated in HG-induced hRMECs through reduced angiogenesis, proliferation, and migration in vitro (128)
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Additionally, there were also some associations of SOX ( = 0.0243, P = 0.0283, FDR = 0.066) on high cognitive performance, TPO ( = 0.1189, P = 0.0315, FDR = 0.2205) on larger maximum digits remembered correctly, and SOX ( = - 0.2435, P = 0.0395, FDR = 0.1185) on reaction time
The 100mg cohort showed statistically significant reductions in visceral adipose tissue (8.3% vs baseline) and improvements in insulin sensitivity (HOMA-IR reduction of 18.7%), but no hepatotoxicity signals emerged across any dose tier
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