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[11] That doesnt mean injectable GLP-1s are miracle drugs
doi: 10.1056/NEJMoa2306963 65 KosiborodMNAbildstrmSZBorlaugBAButlerJChristensenLDaviesMet al
Previous Hormone Therapy Previous growth hormone or peptide therapy should always be reviewed before beginning a new treatment program
Starting assumptions for a hypothetical 220 lb (100 kg) patient: Baseline BMR: approximately 2,000 calories/day Total daily expenditure (TDEE): approximately 2,400 calories/day (sedentary) Retatrutide effects on the energy equation: Caloric intake reduction: 25-35% (based on food intake data) = 600-840 fewer calories consumed Estimated thermogenic increase: 5-10% of BMR = 100-200 additional calories burned Combined daily deficit: 700-1,040 calories At 48 weeks, this deficit accounts for approximately 54-80 pounds of weight loss, aligning with observed clinical results
Other Small Molecular Targets The receptor activation of cannabinoid (CB)-1/2 involves the production of endocannabinoids, subsequently, endocannabinoids are quickly metabolized by specific fatty acid amide hydrolase (FAAH) (176)
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