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Dysregulation of SQOR has been implicated in mitochondrial diseases 52 , neurodegenerative disorders 53 and ischemiareperfusion injury 48 , highlighting its broader importance in mitochondrial redox metabolism

PubMed - BPC 157 and blood vessels: Review on BPC-157's effects on blood vessels and involvement in tumor biology

And that in some cases of A DHD like that neuroinflammation can really get amped up and hijack the brain

53 Anxiety and the Gut Microbiome Gut microbes are increasingly being recognized as important players in the regulation of social behavior, mood, and pain sensitivity, possibly by impacting amygdala function

Topicals are low barrier entry, microneedling can raise penetration, and injections or mesotherapy require clinic sterility and close follow-up