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GLP-1RAs attenuate systemic and local inflammation by inhibiting the p38 MAPK/NF-B pathway, reducing cytokine production, endothelial injury, and microvascular thrombosis
Tian, J.-H
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Larger randomized trials are still needed to understand who is most likely to benefit, how durable the effect is, and why some people may respond more strongly than others
It also drives cortisol higher, which promotes fat storage, especially around the midsection
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