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Int J Mol Sci 21:2440

A combination of increased rates of neuronal glutamate release and reduced glial uptake of glutamate (see below) result in glutamate diffusing out of the synaptic cleft and binding NMDA and metabotropic glutamate receptors outside of the synapse, a process referred to as synaptic spillover

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Intriguingly, even changes in protein translation in stem cells may be driven, at least in part, by NRF2, as mTOR a known regulator of protein synthesis also has a functional ARE (Meng et al., 2018)

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