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These include mono agonists, glucagonlike peptide-1 receptor agonists (GLP-1 agonists), and dual agonists that combine a glucose-dependent insulinotropic polypeptide (GIP) with a GLP-1 agonist (GIP/GLP-1), which have demonstrated a 15% and greater weight loss in people with obesity and/or type 2 diabetes, says Richard E

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Research specifically examining menopausal status found no significant difference in weight loss between premenopausal, perimenopausal, and postmenopausal women using tirzepatide

As for zinc and female fertility, a 2019 study from Robinson Research Institute, Adelaide Medical School, Waite Research Institute, and School of Medical Science found that lower levels of zinc in the blood were associated with longer time trying to conceive, so zinc may help a womens fertilization and egg development but there is less research on benefits of zinc supplementation in women

Clinicians should also consider alternative medical explanations for new-onset fatigue, including thyroid dysfunction, anemia, sleep apnea (which may improve or persist despite weight loss), chronic kidney disease, or cardiovascular conditions