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A change in diabetes drug prescribing led to clinical trials of intranasal insulin administration, followed by insulin sensitizers, including metformin and peroxisome proliferator-activated receptor agonists, followed by incretin mimetics targeting primarily GLP-1R (GLP-1RAs) [106]

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Tirzepatide showed a 94% reduction in the risk of developing Type 2 Diabetes over three years in the SURMOUNT-1 pre-diabetic population

For many, the benefits of the medication outweigh this potential, though still uncertain, risk

Will I regain weight when switching from tirzepatide to semaglutide