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Mercer, 2024

Some animal studies suggested a regulatory role of dopaminergic neurons in Gln synthesis 28,50,51

Melanotan I is a synthetic linear tridecapeptide analogue of alpha-melanocyte-stimulating hormone, sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH (CHNO, 1646.9 g/mol, CAS 75921-69-6), catalogued in the literature as afamelanotide, as NDP-alpha-MSH, and in analogue notation as [Nle, D-Phe]-alpha-MSH

However, the extracorporeal circuit has no endothelium to limit these different reactions, which can therefore become excessive and dissiminated throughout the body (Figure 7.22)

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