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Some of the women were also treated with intravenous glutathione
In other words, despite producing significantly greater overall weight loss than semaglutide or tirzepatide, retatrutide did not cause a disproportionately higher percentage of muscle loss (Coskun et al., Lancet Diabetes Endocrinol , 2025)
Given that several further dual agonists are coming closer to becoming licenced, such as mazdutide and survodutide, with many more in development [15], combining licenced dual agonists with developing mono-agonists may be a faster way to develop effective treatments achieving triple agonism
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Tesamorelin is a synthetic analogue of GRF used to increase GH and IGF-1, particularly in the context of HIV-related lipodystrophy
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