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For decades, fiber was viewed simply as "roughage"inert material that added bulk to stool and aided in mechanical digestion
2 illustrates these effects in humans [8,16]
This latter effect results in a reduced capacity for removal of cholesterol from lipid-laden macrophages (foam cells) leaving the foam cells in a more pro-inflammatory state
This means that their findings may not be fully generalizable to other settings. They also note that their records only show whether a medication was dispensed to a patient and not whether they took it as prescribed
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