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Chronic pain often involves nervous system sensitization, metabolic dysfunction, nutrient depletion, or low-grade inflammation that may not appear on standard imaging or routine laboratory tests
As patients reduce food intake and sometimes forget to maintain fluid consumption, their overall hydration status declines
That tells us appetite suppression is fundamentally a brain-mediated effect. The brain contains multiple, overlapping circuits that regulate feeding
LIMITATIONS Several notable limitations warrant consideration
Patients should confirm how their patient-specific medical needs are documented
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