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GIP receptors are also found in areas of the brain associated with satiety and reward signaling.When tirzepatide activates both receptor types, it: Tirzepatide's actions on blood sugar are glucose-dependent, meaning it: Additional systemic effects include: Talk with your provider if you are pregnant, plan to become pregnant or breastfeed, or have a history of: Some side effects require prompt medical attention, including: Your knownwell care team will review your health history, medications, and safety considerations before prescribing Zepbound and will continue to support you throughout treatment