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Additionally, semaglutide has been observed to slow down gastric emptying, which contributes to prolonged sensations of fullness and further aids in reducing overall caloric intake

This study was IRB approved and was conducted in accordance with the Declaration of Helsinki

During GLP-1associated weight loss, lean-mass changes are typically adaptive and preventable , not degenerative. GLP-1 Body Composition Changes: What Clinical Trials Show About Muscle Loss Clinical trials and body-composition sub-studies of semaglutide and tirzepatide consistently demonstrate: Fat mass accounts for most weight lost during treatment. Lean mass may decrease , particularly without resistance training or adequate protein intake. In many patients, the proportion of lean mass relative to total body weight is preserved or improved , because fat loss exceeds lean loss. Key clinical insight: GLP-1/GIP therapies improve overall body composition by preferentially reducing fat massnot by causing muscle breakdown. Lean mass refers to all the non-fat tissues in the bodyprimarily skeletal muscle , but also organs, bones, connective tissue, and body waterthat support metabolism, movement, and overall physical function

However, those researchers reported that the effects were short-term and that there was no long-term association between semaglutide and increased progression of diabetic retinopathy during the studys 3-year period