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Rodents treated with GLP-1 receptor agonists demonstrated reduced joint inflammation, decreased synovial proliferation, and lower levels of inflammatory cytokines compared to untreated controls

For example: At 0.25 mg semaglutide from a 5 mg/mL vial, you only draw 0.05 mL, delivering just 0.025 mg (25 mcg) of B12 At 2.4 mg from the same vial, you draw 0.48 mL, delivering 0.24 mg (240 mcg) of B12 The recommended daily intake of B12 for adults is 2.4 mcg

AOM tirzepatide, in contrast, began lower at 0.3% in January 2024, but grew rapidly, surpassing prescribing rates of AOM semaglutide by late 2024

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