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GLP-1 receptor agonists were first approved by the Food and Drug Administration (FDA) for the treatment of type 2 diabetes

Reverse research inducing cirrhosis in mice showed that cirrhosis leads to dysfunction of the intestinal barrier, and found that FXR agonists can ameliorate the translocation of gut bacteria to the liver by restoring the integrity of the gut-vascular barrier (Sorribas et al., 2019)

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They appear in the spinal cord, the brainstem, the trigeminal nucleus, and in peripheral sensory neurons