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Long-term use should be supervised and monitored by a healthcare professional
Individual results vary considerably
The reason why isotretinoin is not approved in Japan is that acne is not a disease that causes physical discomfort and is often interpreted as a cosmetic rather than a disease treatment, making it difficult to approve drugs with serious side effects such as teratogenicity
Moreover, whenever a patient with fibromyalgia scratches his skin to relieve itching, it causes skin breakage and damage that leads to severe itching and pain
& Dawborn, J
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