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While some studies have contributed to a better understanding of viscosity-reducing excipients, our understanding is insufficient to enable rational excipient selection based on prior knowledge of the protein molecular properties (e.g., surface heterogeneity, charge, hydrophobicity)

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The 44% reduction in histological degeneration scores is a clinically meaningful finding

GLP-1 research peptides are primarily used in diet-induced obesity (DIO) mouse models, ob/ob and db/db genetic models, oral glucose tolerance tests (OGTT), insulin tolerance tests (ITT), and in vitro receptor binding and cAMP signaling assays