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Similar to Wegovy coverage is limited to states that include obesity-indicated GLP-1s and, more recently, to its sleep apnea indication in some states

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NF-kB pathway inhibition Nuclear Factor-kappa B is one of the master regulators of inflammation in the human body

Its worth noting that about 10% of patients discontinue GLP-1 therapy due to these side effects, so careful dose adjustments can significantly improve tolerability

Original unopened vials are described as remaining refrigerated until their expiration date, typically 24 to 36 months out, whereas an in-use vial at room temperature is the common active-treatment scenario with a much shorter window