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cAMP accumulation concentration-response curves were also analysed using an operational model of agonism modified to directly estimate the ratio of / K A using Eq

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Gastrointestinal adverse events - predominantly nausea, vomiting, diarrhea, and constipation - are the most common class effects, occurring in 20%-60% of patients depending on the agent and dose, and are typically of mild-to-moderate severity, dose-dependent, and most prominent during titration

doi: 10.1186/s40478-021-01180-z 117 YunSPKamTIPanickerNKimSOhYParkJSet al