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Pharmacologically this yields a highly selective GHS-R1a agonist which, in classical rodent studies (Raun et al., Eur J Endocrinol 1998), does not significantly elevate cortisolemia, ACTH, prolactin or FSH/LH at effective doses, unlike GHRP-2 and GHRP-6
Over time, the body may adapt to this state and compensate by taking in more calories, which can offset weight loss
Weight and blood pressure should be monitored at routine appointments
In general, tirzepatide tends to produce similar rates of nausea but potentially different patterns of gastrointestinal effects due to its additional GIP receptor activity
If it's discolored, clumped with moisture, or stuck to the vial wall in a way that suggests it's been liquid before, contact the pharmacy
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