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Song et al showed that decreasing periplasmic GSH by deleting the GSH exporter CydD triggers the CpxR/SoxS two-component systems, upregulating the AcrAB-TolC pump and lowering intracellular drug accumulation
However, the second burst of activation happening in mid-late G1 phase was lowered in Gstp1/2 / mice, and the downstream inductions of Cyclin D1 and its catalytic partner CDK4 were delayed
We have written to all four Ministers for Health of the constituent countries in the UK, as well as their Chief Medical Officers
Abdelkader H, G
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