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IRS recruitment activates phosphoinositide 3-kinase (PI3K), which phosphorylates PIP2 to PIP3, recruiting Akt/PKB to the membrane for activation by PDK1 this PI3K/Akt arm drives protein synthesis via mTORC1, glucose uptake via GLUT4 translocation, and cell survival via BAD phosphorylation

According to NICE guidance (NG28), treatment intensification should be considered when HbA1c rises to 58 mmol/mol (7.5%) or higher on dual therapy

67 Furthermore, removal of refined carbohydrates from the diet, which has been suggested as an empiric treatment to improve the behavioral fluctuations, gastrointestinal symptoms and dysbiosis in ASD, 8 may act by reducing substrate for these bacteria to produce PPA

The GLP-1 biosimilars market is gaining significant momentum, driven by the global surge in obesity and type 2 diabetes prevalence, escalating healthcare costs, and the growing need for accessible treatment options

We take FCF as ~100% of net income in normal years