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At the class level, both have a GI-dominant profile (nausea, vomiting, diarrhoea) that concentrates at dose escalation

The glucose infusion rate was adjusted according to blood glucose levels until a first euglycemic steady state was reached (from ~70 to 100 min of infusion) and similarly adjusted until a second euglycemic steady-state was reached (from ~150 to 210 min of infusion)

The variant was built specifically to escape the regulatory layer that governs native IGF-1 availability

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