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N Engl J Med 373:22472257 Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB (2016) LEADER Steering Committee
Most herbal alternatives, including ingredients like chromium picolinate, garcinia cambogia, and conjugated linoleic acid, show modest effects in small studies but lack the sustained appetite suppression and metabolic changes documented in semaglutide trials
GLP-1 slows gastric emptying, increases satiety, and triggers insulin release after meals
There were 16/128 (13%) GLP-1RA users with retained gastric contents when bowel prep was not used, vs
No difference in the need for definitive therapy was observed
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