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This imbalance between sympathetic and parasympathetic activity leads to resting tachycardia, reduced HRV, orthostatic hypotension, and an increased risk of silent myocardial ischemia and sudden cardiac death

Folinic acid (2 mg/kg/day, max 50 mg/day) produced significantly greater improvements in standardized verbal communication scores and several adaptive and behavioral subscales compared with placebo, with a stronger effect on children ( Furthermore, a placebo-controlled randomized trial evaluated the efficacy of folinic acid (5 mg twice daily) for 12 weeks in 19 children aged 310 years (sex distribution not reported) with ASD diagnosed by ADOS, without genetic syndromes, major medical comorbidities, or treatments affecting folate metabolism

Sometimes the change will only last a few days and revert back to the previous health state