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(1) When you take semaglutide, the resulting insulin that is produced sends signals to the part of the brain that is responsible for feelings of hunger- the hypothalamus

This does not mean semaglutide is not working

more likely related to rapid weight loss than the medication itself Telogen effluvium (temporary hair shedding) is reported by some patients during periods of sustained rapid weight loss Injection site reactions Usually mild and short-lived

doi: 10.3389/fimmu.2025.1713426 Received 26 September 2025 Revised 13 December 2025 Accepted 19 December 2025 Published 24 March 2026 Volume 16 - 2025 Edited by Daniel P

4 Related Stories GLP-1 weight loss may reduce first-impression penalties in relationships and hiring GLP-1 drugs may reduce lung scarring from Long COVID in diabetic patients Blood ketone threshold may help predict weight loss success Non-peptidic small-molecule GLP-1R agonists, such as orforglipron, and other investigational agents are intrinsically resistant to proteolysis and do not require permeation enhancers or fasting administration