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3 As a result, GLP-1 medications may bind less effectively, reducing insulin secretion, delaying satiety signaling, and limiting overall metabolic response

Additionally, the administration of oral GLP-1 drugs requires strict guidance: for example, semaglutide must be taken on an empty stomach in the morning, with no more than 120 mL of water, and patients must wait at least 30 minutes before having breakfast

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