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GLP-1 therapies have been shown to help patients lose 1520% of their body weight when combined with healthy lifestyle changes

Temporary hair loss can appear about three months after rapid weight loss and may take up to six months to resolve

In the Phase 2 obesity trial published in NEJM in 2023, retatrutide at the 12 mg weekly dose produced a mean placebo-adjusted body weight reduction of 22.1 percentage points (22.1% (24.2% arm) mean absolute reduction on the retatrutide arm) at 48 weeks (Jastreboff et al., NEJM, 2023)

Side effects are typically mild and attributable to GLP-1 (nausea, constipation, appetite loss during dose escalation) rather than TRT interaction

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