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APAP administration promotes apoptotic-response and regenerative in the adult fat body In vertebrate systems, APAP administration is associated with massive necrosis, possible apoptosis, and a prompt regenerative response 33,34

Although brain infarction volume reduction did not reach statistical significance, motor performance in the rotarod test significantly recovered in DSIP-treated animals compared to vehicle controls confirming a functionally relevant neuroprotective effect at the behavioural level and establishing intranasal delivery as a viable route for CNS DSIP research

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