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We therefore created novel ovarian tumour cell line models in which GSTP1 expression is stably deleted, to investigate whether differential GSTP1 expression directly influenced chemosensitivity to platinum drugs, and to other drugs routinely used in the treatment of ovarian cancer patients

It participates in the Fenton reaction a chemical process that generates hydroxyl radicals, one of the most damaging reactive oxygen species known [3]

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AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance