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The average concentration of glutamate in the brain is around 12 mol/g, in synaptic vesicles it exceeds millimolar concentration, however the glutamate level in extracellular fluids is only 0.52 mol/l (ECF) (Hawkins 2009
J.et al (2011)
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3.4.3 Mechanistic insights from preclinical modelsbarrier, immune, and neurotransmitter changes Rodent models of PTSD provide causal evidence that psychological trauma disrupts the MGBA, leading to microbiota alterations, compromised gut barrier integrity, immune activation and neurotransmitter imbalance
Anti-aging protection Oxidative damage accelerates aging at the cellular level
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