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10.3389/fcell.2020.598148 50 DiasG

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Essentials of human embryology

however, in the case of injury or disease, loss of NMNAT activity leads to NAD + depletion and NMN accumulation, which in turn activates SARM1 53,54,289

Importantly, mTOR inhibition (e.g., via rapamycin) helps maintain astrocytes in a protective state and reduces neuronal lipid peroxidation damage (Zhang et al., 2025c)