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GLP-3 is an informal designation in the research community reflecting retatrutide's position as the third generation of GLP-class metabolic peptides (after GLP-1 monoagonists and GLP-1/GIP dual agonists)

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additionally NAD + can be generated in the mitochondria from NMNAT3 80 , whose activity has been shown to be required in cells 77 , but dispensable in vivo as NAD + can be replenished through other pathways such as import from the cytosol 81

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