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Since several ATGs and lysosomal cathepsin proteases depend on cysteines for their activities they can be the sensors or transducers of changes in the intracellular redox state through mechanisms involving redox signaling
Int Food Res , 33 , 409421
This clearly supports the impact of thiol levels on artemisinin sensitivity and we then demonstrated that SFN, an available and safe molecule derived from broccoli sprout, can potentiate artemisinin activity both in vitro and in vivo in artemisinin resistant parasites
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Cell 9 , 29052916 (1998)
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