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The statistical analyses were performed using Prism9 GraphPad and generally included a ROUT outlier analysis

DSIP differs from more pathway-specific compounds such as Epitalon and Orexin in that it does not act through a single defined receptor or molecular axis

The STEP trials with over 4,500 participants showed semaglutide reduced triglycerides by 23% and LDL cholesterol by 6%, complementing statin therapy without significant drug interactions