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mRNA2
Most users resume or increase exercise intensity during months 4-6 as energy levels normalize and tolerance improves
In the STEP 1 trial published in the New England Journal of Medicine (2021), participants receiving semaglutide 2.4 mg weekly achieved an average weight loss of approximately 15% of body weight over 68 weeks, compared to 2.4% with placebo
Rapid hepatic metabolism blunts the endocrine action of portally infused GLP-1
Employers looking to add GLP-1 drug coverage specifically for weight loss to their health plans will be best-served by working in conjunction with clinical data experts who can help assess benefit design, address potential increases in drug spending, and incorporate healthcare benefits with effective behavioral modification and support programs
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