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The synovium, which mainly consists of immunocytes and fibroblast-like synoviocytes (FLS), despite not being the sole tissue implicated in OA-related inflammation, represents a major site of gross and microscopic inflammatory alterations [129]
This condition is defined by physiological and cognitive alterations that profoundly impair the persons ability to function, along with feelings of sorrow, emptiness or irritability
[15] Animal studies in vivo An in vivo study in aging mice found that epitalon treatment significantly reduced the incidence of chromosomal aberrations, both for wild-type mice and for mice characterized by an accelerated aging phenotype, which is consistent with increases in telomere length
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