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In this context, it has been reviewed that certain substances can stimulate tumor cell apoptosis and, by the same token, inhibit eryptosis, which may avoid side effects such as anemia found in cancer patients subjected to chemotherapy
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doi:10.5603/AIT.2015.0015
In addition, a further study showed STAT3 upregulation was associated with GH hypersecretion in pituitary somatotroph adenomas (73)
This makes it a common reference point in research comparing systemic versus localized growth factor delivery, and it is one reason IGF-1 LR3 shows up so frequently alongside mechano growth factor in muscle physiology literature
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