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[2] However, monodehydroascorbate is a radical and if not rapidly reduced it disproportionates into ascorbate and dehydroascorbate (DHA)

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While systemic dihexa half life remains one to two hours, CNS concentrations may persist for four to six hours because the peptide is delivered to the target site without requiring blood-brain barrier penetration

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Impaired neuro-progression, which results in somatic symptoms including anhedonia, anxious behavior, fatigue, discomfort, and psychiatric symptoms such as mild cognitive impairment (MCI), is associated with the progression of depression (71, 72)