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G6PD catalyzes the rate-limiting step in the pentose phosphate pathway, which provides nucleotide precursors for DNA replication as well as cytosolic reducing equivalents of the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)

The current understanding is built upon a large body of preclinical evidence from animal studies on similar connective tissues

Published preclinical and in vitro research has examined its interaction with extracellular matrix remodelling, broad gene-expression modulation, antioxidant and anti-inflammatory pathways, and copper-coordination chemistry in cultured fibroblasts and animal wound models

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However, there are also new drugs approved by the FDA each year but have no assigned code at the time of approval