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Meanwhile, the nanoformulation-enhanced membrane interaction could influence ECM remodeling more directly, optimizing the MMP/TIMP balance, as shown by Taherkhani et al
doi: 10.1136/annrheumdis-2020-217251
A randomised cross-over clinical trial has shown that, compared to the standard administration route, direct delivery within the urethral meatus can increase efficacy and confidence among patients, without increasing adverse effects [446]
The severe deficiency of this enzyme results in a reduction of the NADPH generation, which results in a decrease in the production of hydrogen peroxide (H 2 O 2 ) and therefore the neutrophil microbicide activity is affected and likewise its inflammatory response 16
Gastrointestinal side effects (flatulence, diarrhoea) may limit tolerability
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