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Since they work using energy they can transport substances against the concentration gradients, some efflux pumps present on the BBB are P-glycoprotein (P-gp), the breast cancer resistance protein and various drug resistanceassociated protein, organic anion transporters, organic anion transporting polypeptides, etc

Hershman of Columbia University in New York, so this is not like a lot of studies where you find a statistically significant difference thats not clinically meaningful. In addition, the incidence of grade 3/4 neurotoxicity was 3.8% with ALC, much higher than the 0.5% seen with placebo

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