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PPAR-mediated microglial activation phenotype is involved in depressive-like behaviors and neuroinflammation in stressed C57BL/6J and ob/ob mice
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Many preclinical and clinical studies have indicated the accumulation of oxidative burden in chondrocytes undergoing osteoarthritic changes 39,40
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Since then, numerous studies have been done to understand the GPx-like catalytic mechanism of ebselen and to test its potential as a therapeutic invention for preventing or treating oxidative stress-related disorders [76]
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