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537 Using the FGFR2 -based splicing reporter as a readout, a recent preclinical study identified compounds such as nemadipine-A (a T-type calcium channel inhibitor), NNC-55-0396 dihydrochloride (a L-type Ca channel inhibitor), and naltrexone hydrochloride (an opioid antagonist) that change FGFR2 splicing and induce an epithelial phenotype in PCa cells
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However, omeprazole's enteric-coated formulation is designed to protect it from stomach acid and allow absorption in the small intestine, which helps mitigate potential absorption issues related to delayed gastric emptying
Blood 125 , 18031812 (2015)
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