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For someone with a history of restrictive eating, the dramatic appetite suppression could potentially trigger unhealthy patterns

In their separate trials, the top licensed doses of Mounjaro and Wegovy produced average reductions of 22.5% (SURMOUNT-1) and 20.7% (STEP UP), though no study has directly compared the three

Although clinical studies have not demonstrated overt systemic depletion of NAD(P) during GLP-1RA therapy, sustained reductions in nutrient inflow may influence precursor availability and turnover kinetics, particularly in metabolically stressed populations